Chlorine Dioxide and stem cell activation: a new dimension in regenerative therapies
Presentation of a 2014 Chinese patent on the subject
I have previously covered the versatile applications of chlorine dioxide (ClO₂) in several Substack articles (listed at the end of this post), discussing its antibacterial, antiviral, anti-inflammatory, oxidant and antioxidant, and detoxifying properties. For those unfamiliar with the topic, one of the best summaries is the Universal Antidote documentary, which I have subtitled in Hungarian. It provides a comprehensive overview of how ClO₂ may help combat various diseases. If you’re new to this field, I recommend starting with that documentary for a deeper understanding.
However, beyond these well-known effects, there exists a lesser-known but highly promising mechanism of ClO₂, detailed in a 2014 Chinese patent. I have not yet seen this aspect covered in detail anywhere else. This research and documentation suggest that chlorine dioxide can not only aid through the previously mentioned mechanisms but also activate naturally occurring stem cells in the body, thereby promoting the regeneration of damaged tissues.
When we think of stem cells, we often associate them with laboratory procedures that involve introducing external cells, as in stem cell therapy or regenerative medicine. However, the human body already possesses stem cells with regenerative potential, found in the bone marrow, adipose tissue, bloodstream, and various other tissues. These stem cells can remain dormant, but when activated, they have the capacity to generate new tissues, regenerate damaged organs, cartilage, nerve cells, and other cell types.
The findings of the patent suggest that ClO₂ does not work by introducing external stem cells but rather by activating the body’s own existing stem cells, stimulating their migration and differentiation. This discovery could open entirely new possibilities in regenerative therapies, particularly in the treatment of chronic and degenerative diseases where the body’s self-healing capabilities play a crucial role.
In this article, I will explore this new aspect of ClO₂—how it stimulates stem cells, what clinical trials have validated this effect, and what potential applications it may have in the future. This research could further expand the role of chlorine dioxide in modern regenerative medicine and pave the way for new treatments for tissue deficiencies and degenerative diseases.
It only needs to break through the closed doors of regulatory agencies—doors that the pharmaceutical industry keeps under strict control. As the saying goes, "small but mighty," and if that holds true, then ClO₂ possesses an even greater force. A single tiny molecule that could become a serious competitor to many expensive drugs—precisely why every effort is made to keep it outside the gates of mainstream medicine.
The translation of the Chinese patent discussed in this article was conducted using multiple translation programs and artificial intelligence. While I have made every effort to provide the most accurate interpretation, translation errors or misinterpretations may still occur. Therefore, the treatment methods and applications presented here serve solely as a scientific discussion and should not be considered medical advice or a clinically validated therapy. Those who wish to understand the original text precisely are encouraged to read the attached Chinese patent and seek professional translation services to verify the information.
Here is the original patent:
Mechanisms of Stem Cell Activation by Chlorine Dioxide (ClO₂) According to the Patent
Controlled Induction of Oxidative Stress
ClO₂ generates mild oxidative stress in the body, creating artificial micro-injuries. This controlled cellular damage activates the body's regeneration mechanisms and stimulates stem cell activation. The level of oxidative stress does not reach harmful levels that could damage healthy tissues, but it is strong enough to enhance stem cell mobilization.
Activation of CD34+ and CD31+ Progenitor Cells
According to the patent, ClO₂ increases the number of CD34+ and CD31+ cells in the bloodstream, which are crucial for vascular and tissue regeneration.
CD34+ cells are progenitor cells involved in the regeneration of blood vessels and other tissues.
CD31+ cells are precursors to endothelial cells, playing a key role in new blood vessel formation.
Promotion of Stem Cell Migration and Differentiation
Under the influence of ClO₂, stem cells mobilize from the bone marrow and other tissues and migrate to damaged areas (stem cell migration). The patent describes that these stem cells then differentiate into tissue-specific cell types (e.g., cardiomyocytes, neurons, chondrocytes) based on environmental signals.
Activation of the Wnt Signaling Pathway
The document highlights that ClO₂ activates the Wnt signaling pathway, which is crucial for stem cell renewal and regenerative processes. This pathway regulates cell division, differentiation, and the formation of new cells, particularly in regenerating tissues such as hair follicles, neurons, and other cell types.
Anti-Inflammatory and Immunomodulatory Effects
ClO₂ not only activates stem cells but also reduces the levels of inflammatory cytokines (e.g., IL-6, TNF-α), which can inhibit stem cell function. This is particularly important for patients with autoimmune and inflammatory diseases, as ClO₂ can normalize immune responses, allowing stem cells to perform their regenerative functions more effectively.
Supporting the Survival of Newly Formed Cells
ClO₂ enhances the viability of newly formed cells by improving tissue oxygenation and reducing oxidative damage. This is especially important for tissues where hypoxia (oxygen deficiency) is a common regenerative barrier, such as post-myocardial infarction tissue and neurological injuries.
Summary
According to the patent, ClO₂ does not introduce external stem cells into the body but stimulates the body's natural regenerative mechanisms by activating and mobilizing stem cells and progenitor cells present in the bone marrow, blood, and various tissues. The mechanism initiates a natural regeneration process, opening new possibilities in regenerative medicine, particularly in the treatment of chronic diseases, degenerative conditions, and autoimmune disorders.
Studies in the Patent Supporting These Findings:
ClO₂ and Myocardial Regeneration
The document explains that ClO₂ activates the body’s own stem cells, promoting the repair of damaged heart muscle.
ClO₂ significantly enhanced myocardial regeneration by reducing the amount of necrotic tissue and facilitating the formation of new cells.
According to the document, ClO₂ improved myocardial oxygen supply, contributing to better contractility and overall heart function.
ClO₂ and Vascular Regeneration
Studies presented in the document indicate that ClO₂ promoted the formation of new blood vessels (neovascularization), which is particularly crucial for post-myocardial infarction recovery.
The activation and increased number of endothelial progenitor cells (EPCs) were also observed, supporting cardiovascular regeneration.
The treatment reduced inflammatory markers following vascular injury, leading to faster vascular wall repair.
Methods of Application and Dosage
The patent describes various application methods:
Intravenous Injection: ClO₂-containing solution was administered directly into the bloodstream.
Transdermal Application: ClO₂-containing solution was applied through the skin, stimulating local cell regeneration.
Myocardial Infusion: In some animal experiments, ClO₂ solution was infused directly into the myocardium, facilitating cardiac cell repair.
Mechanism
ClO₂ activated CD34+ progenitor cells, which play a key role in the regeneration of the myocardium and blood vessels.
It triggered oxidative signaling pathways, contributing to stem cell activation and new cardiac muscle cell formation.
It reduced inflammatory cytokine levels, which is essential for heart muscle healing.
ClO₂ improved cellular oxygenation and reduced ischemic damage.
Cardiovascular Diseases Treated with ClO₂
The document lists several conditions where ClO₂ treatment may be effective:
Post-myocardial infarction recovery
Myocarditis
Cardiac arrhythmias
Atherosclerosis
Hypertension
Circulatory insufficiency
Safety and Side Effects
ClO₂ administration did not cause significant changes in blood clotting, suggesting it is safe for cardiovascular disease treatment.
A mild, short-term pain was reported at the injection site but resolved within 30 minutes.
No tissue damage was observed following treatment, reinforcing the therapeutic safety of ClO₂.
Effects of ClO₂ on the Treatment of Cerebral Ischemic Damage
According to the document, ClO₂ activated stem cells in the brain and promoted neuronal regeneration, leading to significant improvement following ischemic damage.
It enhanced neuron migration and differentiation, enabling the repair of damaged tissues.
The treatment improved neurological functions and reduced brain inflammation.
Experimental Design and Results
Experimental Groups:
A total of 120 rats were divided into three groups:
Test Group – Received daily ClO₂ solution injections into the carotid artery for 10 days.
Control Group – Received the same volume of physiological saline.
Sham (Mock Surgery) Group – Underwent surgery without occlusion of the middle cerebral artery.
Neurological Assessment:
Motor coordination and reflexes were evaluated daily, showing significant improvement in the ClO₂-treated group.
Based on the Longa Neurological Scale, ClO₂-treated animals demonstrated faster recovery compared to the control group.
Stem Cell Activation and Cell Proliferation:
Increased presence of BrdU (bromodeoxyuridine) and GFAP (astroglial marker) positive cells indicated neuronal regeneration and stem cell activation.
Mechanism
Stem Cell Activation and Neuronal Regeneration:
ClO₂ promoted migration and proliferation of neural stem cells following ischemic brain injury.
It stimulated the differentiation of neural progenitor cells (NPCs), supporting nervous tissue repair.
Anti-Inflammatory Effects:
ClO₂ reduced excessive activation of microglia and astrocytes, which contribute to inflammation after ischemic injury.
Levels of inflammatory cytokines (IL-6, TNF-α) decreased, aiding in the healing of damaged brain tissue.
Reduction of Oxidative Stress:
Through its antioxidant mechanisms, ClO₂ lowered reactive oxygen species (ROS) levels, reducing oxidative stress.
Methods of Application and Dosage
Intracarotid Injection:
ClO₂ solution was injected directly into the carotid artery to maximize brain bioavailability.
Dosage: ClO₂ solution administered once daily for 10 days.
Safety and Side Effects
The treatment was well tolerated, with no significant side effects observed.
Physiological parameters of the animals remained stable, and no toxic reactions were reported.
The control group showed no significant regeneration, whereas the ClO₂-treated animals demonstrated improved brain function.
Effects of ClO₂ on the Treatment of Osteoarthritis
According to the document, ClO₂ activated the regenerative processes of joint cartilage, contributing to the long-term restoration of joint health.
It reduced inflammation and pain, as confirmed by patient evaluations on the VAS (Visual Analog Scale).
ClO₂ promoted synovial fluid production, improving joint mobility.
Experimental Design and Results
Experimental Groups:
The study involved 50 patients diagnosed with knee osteoarthritis.
Patients received daily ClO₂ treatments for six months.
Measurements:
Changes in Knee Cartilage Thickness:
After 3 months, cartilage thickness increased by 9.8%.
After 6 months, cartilage thickness increased by 12.7%.
Pain Relief Effects:
The VAS pain scale score decreased by 89.16% over six months, indicating significant pain reduction.
Medical evaluations showed an 87.12% improvement in joint pain levels.
Mechanism
Stem Cell Activation and Cartilage Regeneration:
ClO₂ stimulated chondrocyte activity and promoted cartilage regeneration.
The restoration of degenerated cartilage occurred through increased cell division, confirmed by histological studies.
Anti-Inflammatory and Pain-Relieving Effects:
ClO₂ inhibited the production of inflammatory cytokines (IL-6, TNF-α), reducing joint pain and stiffness.
By reducing oxidative stress, it slowed the progression of joint damage.
Methods of Application and Dosage
Topical Treatment:
ClO₂ was mixed with DMSO and applied directly to the affected joints.
Frequency: Once daily for six months.
Safety and Side Effects
The treatment was well tolerated, with no severe side effects observed.
Patients reported a mild, temporary stinging sensation in the treated area, which subsided quickly.
No allergic reactions or systemic side effects were detected, confirming the safety of ClO₂.
Treatment of Autoimmune Diseases with ClO₂
ClO₂ modulates immune responses, activates stem cells, and promotes the regeneration of damaged tissues.
Its mechanism of action is complex:
Stem Cell Activation: ClO₂ stimulates the body’s natural regenerative processes.
Anti-Inflammatory Effects: It reduces inflammatory cytokines (e.g., IL-6, TNF-α).
Antimicrobial Properties: ClO₂ effectively eliminates bacteria and viruses that sustain inflammation.
By reducing autoimmune reactions, ClO₂ helps restore normal immune function.
Experimental Design and Results
Autoimmune Diseases Studied:
Rheumatoid Arthritis (RA)
Lupus Erythematosus (SLE)
Psoriasis
Crohn’s Disease
Type 1 Diabetes
Multiple Sclerosis (MS)
Leukopenia (Low White Blood Cell Count)
Thrombocytopenia (Low Platelet Count)
Experimental Groups:
One group received ClO₂-based treatment, while the control group received standard autoimmune therapy.
Observed Effects:
Significant reduction in inflammatory markers (CRP, ESR).
T-cell activity became more regulated, decreasing autoimmune attacks.
80% of patients showed improvement, particularly through reduced inflammation.
Mechanism
Stem Cell Activation and Immune Modulation:
ClO₂ activates stem cells, aiding in the regeneration of damaged organs.
Its oxidative effect induces a mild inflammatory response, which reprograms the immune system.
Antimicrobial and Anti-Inflammatory Effects:
ClO₂ reduces pathogenic bacteria, fungi, and viruses, which can trigger autoimmune responses.
It removes tissue debris and toxins, lowering the likelihood of autoimmune attacks.
Methods of Application and Dosage
Oral Administration:
ClO₂ capsules: 1 capsule per day.
Intravenous Injection:
10 ml ClO₂ solution daily for 14 days.
Transdermal Application:
ClO₂-containing cream, applied once daily.
Safety and Side Effects
The treatment was well tolerated, with no severe side effects observed.
Mild stinging and temporary redness could occur with topical application.
ClO₂ did not negatively impact blood formation or liver function.
ClO₂ and DMSO Combination in Wound Healing and Scar Treatment
In addition to ClO₂’s antibacterial, cell proliferation-stimulating, and oxidative stress-inducing properties, DMSO enhanced absorption, allowing the solution to penetrate deeper tissue layers.
The combined solution effectively reduced scar thickness and hardness while accelerating skin regeneration.
Experimental Design and Results
Experimental Groups:
20 patients participated, each with different types of scars (burn scars, surgical scars, accident-related scars).
Patients received daily ClO₂ + DMSO treatment.
Observed Effects:
After 1 month:
75% of treated patients showed significant scar reduction.
The ClO₂ + DMSO group experienced faster wound healing and less pigmentation.
Scar Thickness and Hardness:
Treated scars became softer, and the surrounding skin integrated better.
Wound Closure Time:
ClO₂ + DMSO-treated wounds healed 30% faster than those in the control group.
Mechanism
Stem Cell Activation and Tissue Regeneration:
ClO₂ induced oxidative stress, which stimulated stem cell migration and proliferation, promoting the formation of new cells.
Microinflammation triggered cell differentiation, reducing scar tissue formation.
Role of DMSO:
Enhanced penetration of ClO₂ molecules into deeper skin layers, boosting effectiveness.
Anti-inflammatory properties of DMSO further supported wound healing.
Methods of Application and Dosage
Topical Treatment:
ClO₂ and DMSO were mixed in a 1:1 ratio.
The solution was applied once daily directly onto the scar tissue.
Left on the skin for 10 minutes, then rinsed off with lukewarm water.
Treatment was repeated twice at 5–7-day intervals.
Dosage and Treatment Duration:
Significant scar reduction was observed after two treatments.
After a 3-month follow-up, 70% of patients experienced near-complete scar disappearance.
Safety and Side Effects
The treatment was well tolerated, with no significant side effects.
Mild stinging sensation occurred upon application but subsided within minutes.
No allergic reactions or systemic side effects were reported, confirming the safety of the ClO₂ + DMSO combination.
Effects of ClO₂ on the Treatment of Androgenetic Alopecia
According to the document, ClO₂ stimulates scalp stem cells and promotes hair follicle regeneration, leading to hair growth.
The treatment induced microinflammation in the scalp, which facilitated the formation of new hair follicles.
ClO₂ activated CD34+ progenitor cells, which play a key role in hair follicle regeneration.
Experimental Design and Results
Experimental Groups:
The study included patients with varying degrees of hair loss, all receiving daily ClO₂ treatment.
Observed Effects:
After 3–5 days, micro-injuries and redness appeared on the treated areas.
After 20 days, new hair began to grow in the treated areas.
The strongest growth occurred in areas where microinflammation was most pronounced.
Hair density and thickness increased, particularly around areas with inflammatory micro-injuries.
Mechanism
Stem Cell Activation and Hair Follicle Regeneration:
ClO₂ induced oxidative stress, which activated CD34+ progenitor cells, stimulating hair follicle regeneration.
The microinflammation promoted stem cell differentiation, similar to the process of wound healing.
Activation of the Wnt Signaling Pathway:
ClO₂ activated the Wnt pathway, which plays a crucial role in new hair follicle formation.
Reprogramming of Scalp Cells:
ClO₂ treatment facilitated hair follicle regrowth by stimulating stem cell differentiation.
Methods of Application and Dosage
Topical Treatment:
ClO₂ solution was applied directly to bald areas.
The solution was applied once daily, left on for 1–2 hours, then washed off.
Dosage and Treatment Duration:
The first treatment cycle lasted 15–25 days.
After a 2–5 month break, a second cycle of 10–15 days followed.
Safety and Side Effects
The treatment was well tolerated, with no significant side effects observed.
Mild stinging was reported at the beginning of application, lasting 15–30 minutes before subsiding.
No allergic reactions or systemic side effects were noted, confirming the safety of ClO₂ treatment.
Effects of ClO₂ on the Treatment of Deep Vein Thrombosis (DVT)
According to the document, ClO₂ activated vascular progenitor cells (EPCs) and promoted vascular wall regeneration, aiding in the repair of damaged veins.
The number of CD34+ and CD31+ cells in circulation significantly increased after treatment, indicating stem cell activation.
The treatment reduced limb edema, as confirmed by volume measurements.
Experimental Design and Results
Experimental Groups:
20 patients with lower limb DVT participated in the study.
They received daily ClO₂ treatments for 14 days.
Observed Effects:
· CD34+ Cell Levels in Blood:
Before treatment: 0.38 ± 0.42% (low level).
After 7 days: 0.91 ± 0.51% (significant increase).
After 14 days: 1.4 ± 0.68% (more than a threefold increase).
· CD34+/CD31+ Cell Levels in Blood:
Before treatment: Low.
After 7 days: Significant increase.
After 14 days: Further increase.
· Reduction in Limb Edema:
Volume measurements confirmed a significant decrease in leg circumference after treatment.
Mechanism
Stem Cell Activation and Vascular Regeneration:
ClO₂ stimulated circulating endothelial progenitor cells (EPCs), which aided in repairing damaged vascular walls.
The treatment promoted new blood vessel formation (angiogenesis) and accelerated venous regeneration.
Anti-Inflammatory Effects:
ClO₂ reduced inflammatory cytokines (IL-6, TNF-α), facilitating faster healing.
Antithrombotic Effects:
ClO₂ promoted fibrinolysis and natural clot breakdown, while not significantly affecting blood coagulation parameters.
Methods of Application and Dosage
Intravenous Injection:
ClO₂ solution was injected into the opposite femoral artery of the affected limb.
Dosage: 10 ml ClO₂ solution daily via intravenous injection.
Dilution: 5× diluted with physiological saline solution.
Safety and Side Effects
The treatment was well tolerated, with no significant side effects observed.
Coagulation parameters (APTT, PT, TT) remained stable, indicating no increased bleeding risk.
Patients experienced temporary stinging at the injection site, which subsided within 30 minutes.
Effects of ClO₂ on the Treatment of Alopecia Areata
According to the document, ClO₂ activated scalp stem cells and promoted hair follicle regeneration, resulting in significant hair regrowth.
The applied solution stimulated CD34+ progenitor cell differentiation, contributing to the formation of new hair follicles.
The treatment activated the Wnt signaling pathway, which plays a crucial role in skin regeneration and hair follicle development.
Experimental Design and Results
Experimental Groups:
30 patients diagnosed with alopecia areata participated in the study.
Patients received daily ClO₂ treatment for 15–25 days, followed by a 2–5 month break, after which another treatment cycle was administered.
Observed Effects:
After 3–5 days, micro-injuries and redness appeared in the treated areas.
After 20 days, hair regeneration occurred in the treated areas.
Hair growth significantly increased around the micro-injury sites, and hair strands became thicker.
Efficacy Against Hair Loss:
ClO₂ treatment showed greater effectiveness than conventional treatments such as minoxidil or finasteride.
Mechanism
Stem Cell Activation and Differentiation:
ClO₂ induced oxidative stress, which activated CD34+ progenitor cells, stimulating hair follicle regeneration.
The treatment caused microinflammation, promoting the formation of new hair follicles, similar to the wound healing process.
Role of the Wnt Signaling Pathway:
ClO₂ activated the Wnt pathway, enhancing new follicle regeneration and cell division processes.
Skin Irritation and Wound Healing:
The solution induced micro-injuries on the scalp, stimulating the healing process and promoting hair follicle regeneration.
Methods of Application and Dosage
Topical Treatment:
ClO₂ + DMSO mixture was applied directly to patchy bald areas.
The solution was applied once daily and washed off after 1–2 hours.
Dosage and Treatment Duration:
First treatment cycle: 15–25 days.
After a 2–5 month break, a second cycle of 15–25 days was administered.
Safety and Side Effects
The treatment was well tolerated, with no significant side effects observed.
A mild stinging sensation was reported at the application site but subsided quickly.
No allergic reactions or systemic side effects were noted, confirming the safety of ClO₂ treatment.
Effects of ClO₂ on the Treatment of Ankylosing Spondylitis (AS)
According to the document, ClO₂ facilitates stem cell activation and migration, thereby reducing inflammationand promoting joint regeneration.
It improved mobility and reduced pain, as confirmed by objective clinical measures (BASDAI, BASFI, ESR, CRP).
ClO₂’s immunomodulatory effects helped regulate autoimmune processes, slowing disease progression.
Experimental Design and Results
Experimental Groups:
12 patients participated, all meeting the modified New York criteria for AS and testing HLA-B27 positive.
Patients received daily ClO₂ treatment in 4 cycles (3 weeks of treatment followed by a 1-week break).
Observed Effects:
Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) scores decreased from 6.4 to 3.0 after treatment.
CRP and ESR values significantly decreased, indicating reduced inflammation.
Mobility tests and joint function measurements showed significant improvement.
Mechanism
Stem Cell Activation and Migration:
ClO₂ stimulated the body’s natural regenerative mechanisms, particularly in affected spinal and joint areas.
Anti-Inflammatory and Immunomodulatory Effects:
The treatment reduced autoimmune-driven inflammation, which is the primary trigger of AS.
Tissue Regeneration:
ClO₂ promoted cartilage regeneration and improved joint flexibility.
Methods of Application and Dosage
Topical Treatment:
ClO₂ mixed with DMSO was applied directly to affected joints.
Applied once daily for 3 weeks, followed by a 1-week break.
This cycle was repeated 4 times.
Inhalation Therapy:
Patients inhaled 2–5 ml of ClO₂ solution daily using a specialized device.
The inhalation treatment lasted for 6 months.
Safety and Side Effects
The treatment was well tolerated, with no severe side effects reported.
Mild and temporary redness and irritation occurred in topically treated areas but resolved quickly.
ClO₂ inhalation did not cause breathing difficulties or oxygen saturation issues.
Effects of ClO₂ on the Treatment of Eczema and Psoriasis
Research presented in the document shows that ClO₂ effectively reduced skin inflammation and promoted skin regeneration.
It eliminated itching and reduced autoimmune activity, which play a major role in both eczema and psoriasis.
ClO₂ cleansed affected skin areas, removed dead skin cells, and helped restore normal skin structure.
Clinical Studies and Results
Eczema Treatment:
12 patients with chronic eczema (average duration: 7 years) participated in the study.
Patients received ClO₂ solution treatment once daily on affected skin areas for 10–15 days.
Observed Effects:
Itching was replaced by a mild stinging sensation, which disappeared within 30 minutes.
After 2–5 days, the skin began to peel, and full regeneration was observed within 10–15 days.
Pigmentation gradually decreased, and skin thickness returned to normal.
Long-Term Effects:
6 patients had no relapse over an 8-month follow-up.
4 patients relapsed once, and 2 patients relapsed twice, but achieved lasting improvement after a third treatment cycle.
Psoriasis Treatment:
86 patients were divided into two groups:
43 patients received ClO₂ treatment.
43 patients were in the control group.
Dosage:
ClO₂ solution was applied once daily to psoriatic lesions.
The solution contained:
10% sodium chlorite (NaClO₂)
2.5% sodium chloride (NaCl)
Activator: 22% citric acid solution
Observed Effects:
74% of ClO₂-treated patients showed significant improvement after 6 months.
Inflammation and scaling disappeared, and skin normalized.
Only 5.7% of treated patients relapsed, compared to 71.9% in the control group.
Mechanism
Reduction of Oxidative Stress and Immune Regulation:
ClO₂ induced oxidative stress, which reduced excessive immune activity and normalized inflammatory responses.
Stem Cell Activation and Skin Regeneration:
ClO₂ stimulated stem cell differentiation, promoting the formation of new skin cells and tissue reconstruction.
Antimicrobial and Immunomodulatory Effects:
ClO₂ exhibited bactericidal and antiviral properties, eliminating triggers of eczema and psoriasis flare-ups.
By normalizing immune system responses, ClO₂ reduced autoimmune reactions associated with psoriasis and eczema.
Methods of Application and Dosage
Topical Treatment:
ClO₂ solution was applied once daily to affected areas.
The treatment cycle lasted 10–15 days and was repeatable if necessary.
DMSO Combination (Advanced Therapy):
DMSO was mixed with ClO₂ to enhance skin absorption and efficacy.
This approach was particularly effective for persistent or recurrent psoriasis cases.
Safety and Side Effects
Mild stinging occurred at the beginning of treatment but subsided quickly.
No significant side effects or tissue damage were reported.
Long-term safety: No adverse effects were observed over an 8-month follow-up period.
Effects of ClO₂ on the Treatment of Type 2 Diabetes
The experiments described in the document indicate that ClO₂ activated pancreatic stem cells, contributing to the regeneration of insulin-producing β-cells.
After 14 days of treatment, blood glucose levels normalized, while no significant changes were observed in the control group.
ClO₂ reduced pancreatic inflammation, which plays a key role in the progression of diabetes.
Experimental Design and Results
Experimental Groups:
Group A (ClO₂ Treatment):
10 rats received 0.5 ml ClO₂ solution directly injected into the pancreas on days 0, 7, and 14.
Group B (Control):
10 rats received physiological saline injections at the same time points.
Measurements:
Blood glucose monitoring:
Fasting blood glucose levels were measured on days 7, 14, 21, and 28 after treatment.
Histological analysis:
Tissue samples confirmed β-cell regeneration through microscopic examination.
Mechanism
Regeneration of Insulin-Producing β-Cells:
ClO₂’s oxidative effect stimulated β-cell regeneration, leading to stable blood glucose levels.
Activation of Stem Cells and Tissue Repair:
Micro-injuries triggered by ClO₂ activated the body's own stem cells, initiating natural repair mechanisms.
Reduction of Pancreatic Inflammation:
By reducing oxidative stress, ClO₂ lowered inflammation in the pancreas, promoting functional recovery.
Methods of Application and Dosage
Injection:
ClO₂ solution was directly injected into the pancreas.
Dosage:
0.5 ml ClO₂ solution (containing 4% NaClO₂ and 1% NaCl) administered as an intrapancreatic injection.
Treatment Schedule:
Injections were given on days 0, 7, and 14.
Safety and Side Effects
The treatment was well tolerated, with no severe side effects observed.
No significant changes occurred in the control group, while ClO₂-treated animals showed stabilized blood glucose levels.
ClO₂ and Postoperative Lung Cancer Recovery
According to the document, ClO₂ administration after lung cancer surgery reduced postoperative complications and accelerated wound healing.
The treatment prevented postoperative infections, often caused by opportunistic pathogens.
ClO₂ stimulated new capillary formation, improving oxygen supply to lung tissues and enhancing regeneration.
Clinical Trial on the Effectiveness of ClO₂
30 lung cancer surgery patients participated, divided into two groups:
15 patients received ClO₂ treatment.
15 patients served as a control group.
The ClO₂ inhalation protocol began on postoperative day 2 and lasted for one month.
Inhalation dosage: Solution was administered in 100 ml plastic bottles for three inhalation sessions per day.
Inhalation duration: 2–10 minutes per session.
Effects and Results
ClO₂ inhalation significantly reduced postoperative inflammatory markers (CRP and ESR).
Lower levels of postoperative edema and inflammation, leading to faster lung function recovery.
Treated patients experienced less breathing difficulty compared to the control group.
Postoperative complications (bronchopleural fistulas, postoperative pneumonia) occurred at a significantly lower rate in the ClO₂ group.
Mechanism
ClO₂’s sterilizing properties reduced the risk of postoperative infections.
Stimulated stem cell activation, accelerating damaged lung tissue regeneration.
Reduced inflammatory responses and promoted new capillary formation, enhancing wound healing and lung function restoration.
Safety and Side Effects
The treatment was well tolerated, with no severe side effects observed.
Mild, temporary throat irritation and coughing occurred in some patients during the first few days but subsided quickly.
ClO₂ inhalation had no negative impact on oxygen saturation or lung function parameters.
Detoxifying and Antioxidant Effects of ClO₂
The document states that ClO₂ reduced reactive oxygen species (ROS), thereby mitigating oxidative stress and enhancing cell survival.
Reduction in oxidative stress was accompanied by increased activity of antioxidant enzymes such as glutathione peroxidase and superoxide dismutase (SOD).
Cellular and Tissue Detoxification
The patent describes ClO₂ as a cellular detoxifier, assisting in the removal of accumulated harmful compounds and supporting healthy cellular function.
ClO₂ activated the body’s natural detoxification mechanisms, particularly in the liver, where it increased the activity of detoxifying enzymes (ALT and AST levels normalized).
Antioxidant and Cell-Protective Effects of ClO₂
ClO₂ neutralized free radicals, preventing cell damage and promoting regeneration.
The treatment had neuroprotective effects, increasing neuron survival rates while reducing inflammatory markers.
Methods of Application and Dosage
Oral Administration:
Capsule form, taken once daily.
Intravenous Injection:
10 ml ClO₂ solution administered intravenously daily for 14 days.
Transdermal Application:
ClO₂-containing cream absorbed through the skin.
Mechanism
ClO₂ removed harmful cellular substances through oxidation.
It stimulated stem cell activation, supporting tissue regeneration.
It enhanced liver detoxification enzyme activity, facilitating toxin breakdown.
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