The Vaccination Paradox: Immune System Weakening? Infection Pressure? The Illusion of Herd Immunity? Placenta-permeable mRNA? Spike protein present in the body for hundreds of days?
The Long-Term Effects of mRNA Vaccines on the Immune System: Increasing Evidence Points to Immunomodulation and Rising Infection Pressure
The widespread application of mRNA-based COVID-19 vaccines has been unprecedented in the history of medicine. While numerous studies have examined the short-term effects of these vaccines, little is still known about their long-term immunological consequences. A study, published in Frontiers in Immunology highlighted that repeated administration of mRNA vaccines can induce immunological changes that may affect the body's natural defense mechanisms against other infections. Simultaneously, the record-high number of influenza-like illnesses observed in the United States and worldwide raises the question: Is there a correlation between changes in the immune system and the increased spread of viruses?
mRNA Vaccines and the Dominance of the IgG4 Immune Response
The Frontiers in Immunology study demonstrated that repeated administration of mRNA vaccines led to an increased proportion of IgG4 antibodies in vaccinated individuals. IgG4 is an antibody associated with the suppression of immune responses. While the first and second doses of mRNA vaccines initially triggered a strong immune reaction (with IgG1 and IgA dominance), repeated booster doses resulted in a significant increase in IgG4 levels.
This phenomenon deserves particular attention from an immunological perspective, as IgG4 is not a defensive antibody but rather one that induces tolerance. For example, in allergy therapy, an increase in IgG4 levels is desirable because it reduces excessive immune reactions to allergens. However, in the case of an active viral infection, this could have harmful consequences, as the body may fail to mount an adequate response to the pathogen, allowing it to persist and replicate for a longer period.
It is important to note that this is not the first study to confirm the shift toward IgG4 dominance in relation to mRNA vaccines.
Previous research has also highlighted this phenomenon, linking it to a weakened immune response against other infections, such as RSV (Respiratory Syncytial Virus), Streptococcus bacteria, influenza viruses, and other respiratory illnesses.
Additionally, a 2022 study published in Nature Immunology suggested that continuous antigen exposure could lead to immune cell exhaustion, particularly affecting T-cell function. This phenomenon is similar to what has been observed in HIV-infected patients, where chronic antigenic stimulation gradually diminishes the immune system's effectiveness over time.
Increased Infection Pressure and Record-High Influenza-Like Illnesses
During the 2024–2025 influenza season, the United States has experienced record-high cases of influenza-like illnesses. According to the CDC, the rate of medical visits for influenza-like symptoms has reached 7.8%, the highest level recorded in the past 15 years. So far, this season has resulted in 24 million influenza cases, 310,000 hospitalizations, and 13,000 deaths.
Other viral infections have also shown significant increases, including RSV and adenoviruses, which have caused more severe illnesses in children and the elderly in recent years. Some studies suggest that these trends may be partially attributed to changes in immune system function, influenced by repeated vaccinations and the weakened immune response following natural infections.
The Population-Level Impact of a Weakened Immune System
If mRNA vaccinations lead to a reduced immune response to pathogens, this does not only affect vaccinated individuals but also has broader consequences for the unvaccinated population. The following factors could be direct consequences of this phenomenon:
Prolonged infection duration: A weakened immune response allows infections to persist longer in individuals, leading to higher viral loads in the community.
Increased transmission potential: If an infected person's immune system fails to eliminate the virus efficiently, the pathogen remains transmissible for an extended period, increasing the risk of further spread.
Higher mutation rates: When a pathogen circulates in a population for longer periods, it has more opportunities to mutate and develop new variants, potentially reducing the effectiveness of existing immunity.
Greater burden on the unvaccinated too: Those who have not received the vaccine face greater infection pressure too, as viruses circulate more aggressively in a population with weakened immune defenses.
Conclusion
Current data indicate that the long-term immunomodulatory effects of mRNA vaccines warrant serious attention. The Frontiers in Immunology study confirms that elevated IgG4 antibody levels are an unusual and potentially problematic immune response, particularly with repeated booster doses.
Epidemiological data, including record-high influenza-like illnesses, RSV infections, and adenovirus outbreaks, suggest that the overall decline in population-level immunity may be increasing the infection pressure worldwide. Further independent research is needed to fully understand the long-term effects of mRNA vaccination on immune system function.
Another Aspect of the Unintended and Unpredictable Effects of Vaccinations Highlighted by the Following Study
Study Summary: The Relationship Between Acellular Pertussis Vaccination and Bordetella parapertussis Infections
Introduction
Acellular pertussis (aP) vaccines are widely used worldwide to prevent whooping cough (pertussis). While these vaccines effectively reduce the incidence of Bordetella pertussis (B. pertussis) infections, growing evidence suggests that they do not provide adequate protection against a closely related pathogen, Bordetella parapertussis (B. parapertussis).This is concerning because B. parapertussis can also cause whooping cough-like illness, and if vaccinated individuals are more susceptible to it, this could have epidemiological consequences.
The goal of this study was to investigate how acellular pertussis vaccination affects B. parapertussis infections in a rodent model.
Methods
Animal Model: The researchers used laboratory mice, divided into two groups:
Acellular pertussis-vaccinated group
Sham (placebo)-vaccinated group
The mice were then exposed to different infection conditions:
Some were infected only with B. pertussis
Others only with B. parapertussis
A third group was infected with both bacteria simultaneously
The researchers measured:
Bacterial load in the lungs
Immune response parameters (e.g., neutrophil count, inflammatory cytokine levels)
Antibody production
Results
The acellular pertussis vaccine effectively reduced B. pertussis levels in the lungs.
However, B. parapertussis bacterial load was 40 times higher in vaccinated mice compared to the control group. This suggests that vaccination facilitated B. parapertussis colonization.
This effect was not due to reduced bacterial competition, as B. parapertussis was still present in higher numbers even when infecting alone, not just in co-infections with B. pertussis.
Mice vaccinated with aP showed a weaker immune response against B. parapertussis, evidenced by:
Lower neutrophil counts (a key component of lung immune defense)
Reduced inflammatory cytokine levels (e.g., IFN-γ, IL-4, IL-5)
B. parapertussis was able to proliferate more easily in vaccinated mice, suggesting that the vaccine suppressed the body's optimal immune response against it.
Conclusions
The results suggest that widespread use of acellular pertussis vaccines could create a population that is more susceptible to B. parapertussis infections.
This poses an epidemiological risk, as vaccination programs may reduce B. pertussis infections while simultaneously promoting the dominance of B. parapertussis.
Epidemiological and Immunological Implications
The study's findings align with the theory that selective vaccination can alter population-level infection dynamics.
One possible explanation is the "Enemy Release Hypothesis" (ERH), which suggests that when a vaccine targets one pathogen, a closely related pathogen may gain an advantage due to reduced immunity against it.
Similar phenomena have been observed with other diseases, such as:
Pneumococcal vaccines – after vaccination, certain bacterial serotypes were suppressed, but others became more dominant (serotype replacement).
Malaria vaccines – some strains evolved mutations that allowed them to better adapt to vaccinated individuals.
This study raises important questions about vaccine strategies, particularly for vaccines that only target a single pathogen. The findings indicate that if a vaccine does not provide broad protection against related pathogens, it could unintentionally create new vulnerabilities in the population.
This research raises important questions regarding vaccination strategies, particularly for vaccines that provide protection against only a single pathogen. The findings suggest that if a vaccine does not offer comprehensive protection against a given infectious disease, it may create new opportunities for other pathogens to thrive within the population.
Conclusion
This study clearly demonstrates that a potential unintended consequence of acellular pertussis vaccination could be the facilitation of B. parapertussis transmission. While the vaccine significantly reduces B. pertussis infections, the shift in immune response creates a more favorable environment for another pathogen. This highlights the need for refining vaccination strategies to optimize their long-term public health impact.
The Risks of Uncontrolled Interventions in the Immune System
This study also sheds light on a critical issue: the human immune system is incredibly complex, yet vaccination programs often operate from a narrow perspective, overlooking long-term and population-level effects.
Unintended Consequences of Vaccines on the Immune System
The acellular pertussis vaccine study is not the first case suggesting that vaccines may not always work as intended and could even have counterproductive effects.
Suppression of Natural Immune Responses – The study demonstrated that the aP vaccine not only failed to protect against B. parapertussis but actually facilitated its proliferation. This supports the hypothesis that vaccines may alter natural immune defenses in a way that benefits other pathogens.
The Myth of Herd Immunity – The concept of herd immunity through vaccination is often used as a marketing strategy in the vaccine industry. The original concept of herd immunity was based on natural infections and the lifelong immunity they provide, not vaccines. The artificially created herd immunity model has never been proven to work long-term, as vaccines do not provide broad or lasting immune protection.
Evolutionary Responses of Pathogens – Another warning sign is that vaccines actively contribute to the evolutionary pressure on viruses and bacteria, leading to their faster mutation and adaptation. This has been observed in:
Pneumococcal vaccines, where certain bacterial serotypes were suppressed, but others expanded rapidly (serotype replacement).
Malaria vaccines, which have driven mutations in certain strains, allowing them to better adapt to vaccinated individuals.
In summary, vaccines do not necessarily eliminate problems—they often simply rearrange them.
"Scientific Consensus" and Data Manipulation
The scientific discourse surrounding vaccines not only lacks a comprehensive understanding, but their alleged benefits are often justified through manipulated data. In the case of the acellular pertussis vaccine, it is evident that while protection against one pathogen appears to be successful, it creates a more dangerous opportunity for another—a fact that mainstream public health authorities rarely acknowledge publicly.
We have observed similar data manipulation in the context of COVID-19 mRNA vaccines, where:
Initial efficacy rates were artificially inflated by using relative risk reduction (RRR) instead of absolute risk reduction (ARR).
No long-term safety or effectiveness data were available, yet the vaccine was rapidly deployed for mass use.
The population-level effects were inadequately studied, particularly concerning long-term immune weakening.
What Are We Seeing Now? Increasingly Frequent and Severe Epidemics
If vaccines were truly effective in reducing infections in the long term, we should be observing the following trends:
✔️ Fewer people contracting illnesses
✔️ Rarer and milder outbreaks
✔️ An overall improvement in immune system health
However, in recent years, we are witnessing the opposite:
❌ Record-high influenza-like illness cases (e.g., 2024–2025 flu season)
❌ Faster spread of new pathogens and mutations (RSV, adenoviruses)
❌ Declining overall health, with rising rates of chronic and cancer-related diseases, indicating an overburdened immune system
Conclusion
The study on acellular pertussis vaccination serves as yet another piece of evidence that humanity continues to interfere with the immune system without fully understanding its complexity. Due to overwhelming commercial interests, scientific findings presented to the public are often manipulated, and the long-term effects of vaccines are never thoroughly investigated.
The formation of herd immunity solely through artificial vaccination has never been scientifically proven—throughout human history, immunity has developed naturally via infections. However, intervention through vaccination may accelerate the adaptation of viruses and bacteria, facilitating the emergence of new variants.
I saved two more shocking recent research finding for last: first study revealed that the S1 protein encoded by the vaccine could circulate in the blood of some individuals suffering from post-vaccination syndrome (PVS) for up to 709 days.
This is a staggering discovery that fundamentally challenges the claim that the spike protein produced by the vaccine rapidly degrades in the body. If it can indeed be detected in the blood of some PVS patients for 709 days, it means that its prolonged presence could potentially trigger chronic immune system issues.
This result is consistent with observations that some vaccinated individuals develop persistent inflammatory processes, autoimmune reactions, and increased susceptibility to infections. If a foreign protein can circulate in the body for such an extended period, it raises the possibility that it continuously stimulates the immune system, potentially leading to immune exhaustion or excessive inflammatory responses.
This issue carries immense public health and scientific significance, and it is imperative that independent researchfurther investigates the prolonged presence of the vaccine-induced S1 protein.
Second study: Transplacental Transfer and Immunogenicity of the mRNA-1273 Vaccine in the Fetus
Introduction
The Moderna mRNA-1273 and BioNTech BNT162b2 vaccines are based on mRNA encoding the SARS-CoV-2 spike protein, encapsulated in lipid nanoparticles (LNPs). These vaccines were widely used during the COVID-19 pandemic and demonstrated more than 90% effectiveness against the disease.
Although mRNA vaccines are considered safe during pregnancy, little is known about their transplacental (placenta-crossing) pharmacokinetics. Previous research suggested that the placenta acts as a barrier to mRNA, as vaccine components were not detected in umbilical cord blood or the placenta in studies conducted weeks after childbirth. The aim of this study was to reassess this claim using a mouse model.
Experimental Methods and Results
1. Transplacental Transfer of mRNA-1273
Pregnant mice were injected with mRNA-1273, and researchers observed that the vaccine mRNA entered the maternal bloodstream within an hour, crossed the placenta, and appeared in the fetal circulation. Although the spike protein-encoding mRNA disappeared from the fetal bloodstream within 4-6 hours, it accumulated in the liver and other tissues, where it was translated into protein.
2. Immunogenicity of the Vaccine in the Fetus
Researchers demonstrated that mRNA-1273 not only provided passive immunity through maternal antibodies but also induced an active immune response in the fetus. After birth, the offspring exhibited anti-spike IgM and IgG2a antibodies, along with an enhanced cellular immune response.
3. The Role of Dosage
The study found that the maternal dose of mRNA-1273 influenced the extent of transplacental transfer and the fetal immune response. Higher doses led to increased mRNA transfer across the placenta and higher antibody levels in the fetuses.
4. Prolonged Presence of the Vaccine in the Fetal Body
Researchers detected that the vaccine mRNA and lipid nanoparticles (LNPs) persisted longer in the fetal body than in the maternal system. Spike protein mRNA was still detectable in the fetal liver and spleen three weeks after exposure, raising questions about potential long-term effects.
Potential Implications and Questions
This study challenges the previous assumption that mRNA vaccines do not cross the placenta. The findings suggest that fetuses develop an active immune response in utero, differing from the purely passive immunity conferred by traditional vaccines (e.g., influenza, tetanus).
Key Concerns:
The prolonged presence of mRNA vaccines in the fetal body raises questions about long-term genetic and immunological effects.
The vaccine may influence the developing immune system and its future function.
The study was conducted in a mouse model, so caution is needed when extrapolating the results to humans.
Conclusion
mRNA-1273 can cross the placenta and elicit an immune response in the fetus. This brings new perspectives on the mechanism of action and long-term effects of mRNA vaccines on developing organisms. The findings underscore the need for further human studies to understand the potential impact of mRNA vaccines on newborns.
At this point, the question is no longer whether these vaccines are causing problems—but rather, how much longer it will take for this to be widely acknowledged.
In analyzing and summarizing the studies presented in this article, I also utilized artificial intelligence, which assisted in organizing the information and identifying correlations.