A Message from an Animal Study to the Future: Silence Around the Ovaries
Just Two Doses of mRNA Vaccine Were Enough to Permanently Destroy a Significant Portion of Female Fertility Foundations in Laboratory Rats
No, this is not some dystopian scenario from a distant future — but the shocking outcome of a peer-reviewed animal study published in 2025.
The study, released in March 2025 in the journal Vaccines, set out to examine how COVID-19 vaccines might affect one of the most fundamental aspects of female fertility: the so-called primordial follicles found in the ovaries — that is, the non-renewable supply of undeveloped egg cells.
Researchers divided female rats into three groups: one group received two doses of the Pfizer–BioNTech mRNA vaccine (on day 0 and day 28), the second group received an inactivated virus vaccine (Sinovac), and the third group received only saline as a control.
The administered dose was the same as the human dose: 0.3 ml per shot, totaling 0.6 ml of mRNA vaccine per rat. At the time of analysis (four weeks after the second injection), researchers conducted microscopic and hormonal analyses of the ovarian tissue.
The results were alarming:
Over 60% of primordial follicles had disappeared in the mRNA-vaccinated group,
The level of AMH — a key fertility hormone — dropped sharply,
Inflammatory and apoptotic markers (TGF-β1, VEGF, caspase-3) increased significantly.
One of the study’s most serious conclusions:
This loss is “irreversible,” because primordial follicles do not regenerate — not in rats, and not in humans.
The Trap of Proportionality — And Why We Still Must Take It Seriously
At first glance, the rat experiment may seem exaggerated. A 250-gram female animal received the same vaccine dose as a 60-kilogram human: two injections of 0.3 ml — a relative dose approximately 240 times higher per body weight.
However, international guidelines (FDA, WHO, EMA) stipulate that animals must receive the full human dose in order to detect even hidden toxic effects. This is not a flaw in the study — it is a regulated, deliberately intensified stress test.
Therefore, the 60% egg cell loss should not be projected directly onto humans. Biological systems do not respond linearly — they often react exponentially rather than proportionally.
But that’s precisely the problem.
Whereas classical inactivated virus vaccines (like the Chinese Sinovac) do harm in proportion to the physical quantity administered, mRNA vaccines actually deliver instructions to cells, prompting them to produce the spike protein for days or even weeks. This is not a “one-time” effect, but a programmed, time-extended protein production — and the immune system’s response can be prolonged and inflammatory.
Moreover, the lipid nanoparticles (LNPs) in the vaccine — according to animal studies — have a special affinity for the ovaries. This means that if LNPs reach the ovaries and the mRNA remains active, the ovarian cells themselves may begin producing the spike protein — triggering inflammation, oxidative stress, and cell death in the most sensitive structures: the primordial follicles.
Thus, although the administered amount may be proportionally lower in humans, the effect can accumulate across time and space. A small dose can do great harm if it reaches the wrong place and stays active for too long. The animal study’s results may not be an exaggeration — they simply reveal in a visible form what may be happening invisibly in humans.
What Happens in the Body After an mRNA Vaccine Injection?
Many people imagine mRNA vaccines to be like traditional vaccinations: the shot is administered, the body reacts, and a few days later the process is over. In reality, however, the mechanism is much more complex.
The mRNA vaccine contains neither the virus nor the spike protein — it carries a genetic instruction.
This instruction (the mRNA molecule) is designed so that the body’s own cells begin to produce a portion of the SARS-CoV-2 spike protein. It is this “internal production” that triggers the immune response.
The mRNA is delivered into cells by lipid nanoparticles (LNPs). These particles are highly efficient at penetrating cell membranes and can migrate from the injection site (typically the upper arm muscle) to other parts of the body.
Biodistribution studies have shown that one of the primary accumulation sites of these LNPs is the ovaries — where the hormonal system, blood flow, and tissue structure seem to make the organ particularly “susceptible” to them.
If these particles reach ovarian cells, they can cause those cells to produce the spike protein for several days — even weeks — locally, right next to the non-renewable egg cell reserves.
To make matters worse, newer studies have revealed that:
mRNA may persist in the body much longer than previously believed — even beyond 180 days
and spike protein has been detected in the bloodstream weeks or even months after vaccination
This prolonged presence can trigger a sustained immune and inflammatory response, which may be especially damaging in sensitive areas like the ovaries. The process is not controlled or localized at the cellular level — instead, it represents a dispersed, long-lasting “hidden activity” that is difficult to measure but may have significant consequences.
This is why the impact of mRNA vaccines is not proportional to the administered dose — because the body becomes a production facility, and the more cells get involved, the greater the potential biological response.
And this type of mechanism may help explain why there appears to be an effect on female fertility in humans — even if the dose is relatively smaller compared to what was used in animal models.
But What About Humans?
The authors of the study — cautiously — call for further human research. But in the meantime, alarming human data has already begun to emerge.
In an independent investigation, researchers compared the rate of successful pregnancies between vaccinated and unvaccinated women in the Czech Republic (and partially in Slovakia).
The Fertility Collapse in the Czech Republic
According to data published by the Association of Microbiologists, Immunologists, and Statisticians (SMIS), a shocking disparity in birth rates between vaccinated and unvaccinated women was observed in the Czech Republic in 2023:
Overall, 68% of women aged 18–39 were vaccinated, while 32% were unvaccinated.
Per 1,000 women:
Among vaccinated women: 42 births per 1,000
Among unvaccinated women: 114 births per 1,000
This means that unvaccinated women were nearly three times more likely to conceive than their vaccinated counterparts.
This difference was so striking that even the Czech government could not easily dismiss it as a mere “natural demographic fluctuation.”
The numbers clearly suggest: something is seriously wrong.
No illness, no infertility diagnosis was necessary. The vaccine alone was enough. Birth rates are already dropping noticeably, while the official institutions shrug—or worse, remain silent.
How could this happen?
Biodistribution studies—which, for some reason, were never emphasized in mainstream news—had already shown that the lipid nanoparticles (LNPs) carrying the mRNA exhibit a particular affinity for the ovaries.
In other words, they accumulate there—and stay there. And what do they do? They cause inflammation, destroy cells, and trigger programmed cell death—in the very organ responsible for passing on life.
And this was made possible by the combined silence and complicity of the state, the healthcare system, the media, and the pharmaceutical industry.
This cannot be dismissed as an accident.
This is targeted, documented, irreversible damage to the source of life. From a single injection.
And consider this: these were only the first two doses.
It’s likely that the researchers didn’t even dare to go further with a third or fourth dose—because even after just two, they found over 60% permanent damage to the ovarian reserve. In other words, the majority of the primordial follicles—those that would have matured into future eggs—were destroyed.
So what remains after additional doses?
Why were we not warned? Why did no one speak up when the first menstrual irregularities appeared?
This experiment wasn’t conducted before the vaccine rollout—it was published five years later, after billions of mRNA vaccine doses had already been administered, including to millions of healthy young women.
Yet if this animal study had been carried out earlier, and its findings made public, one can only wonder:
How many young women would have made a different decision—if they had known their ovaries could be a target?
And why are these products not being pulled immediately, when new studies—including this one—state in black and white:
“Primordial follicles do not regenerate. The damage is permanent.”
If this data applies to humans, even in part—and the Czech numbers strongly suggest it might—then we’re not just talking about individual tragedies, but the dismantling of fertility across an entire generation.
This is not merely a scientific issue.
It is an ethical, societal, and human catastrophe.
And the world remains silent.
Impact of mRNA and Inactivated COVID-19 Vaccines on Ovarian Reserve
(Published in Vaccines, March 24, 2025 – Authors: Karaman E. et al.)
Objective:
The aim of the study was to examine the effects of mRNA-based (Pfizer-BioNTech) and inactivated (Sinovac) COVID-19 vaccines on ovarian tissue and ovarian reserve in a laboratory animal model (female rats), including follicle count, hormonal status, and apoptosis.
Methodology:
Thirty female Wistar albino rats were divided into three groups:
Control group (saline solution)
mRNA vaccine group (Pfizer-BioNTech, human dose)
Inactivated vaccine group (Sinovac, human dose)
Four weeks after the second dose, the rats were euthanized, and their ovarian tissues were removed for microscopic, immunohistochemical, and hormonal analysis.
Markers examined: AMH, TGF-β1, VEGF, and caspase-3 (as an apoptosis indicator).
Results:
Follicle Count
Number of primordial follicles:
Control: ~107
mRNA vaccine: ~42 (~60% reduction, p < 0.001)
Inactivated vaccine: ~70 (moderate reduction)
All other follicle types (primary, secondary, antral, preovulatory) also showed significant decreases, particularly in the mRNA vaccine group.
In contrast, the number of atretic (degenerating) follicles significantly increased in the mRNA group.
This table shows the number of follicles found at various stages of maturation across the three groups:
– Control group (saline solution)
– Group vaccinated with mRNA vaccine (Pfizer-BioNTech)
– Group vaccinated with inactivated vaccine (Sinovac)
Summary of results:
Summary and Interpretation:
The number of all functional follicle types dropped dramatically in the mRNA group.
The primordial follicles—which serve as the foundational reservoir from which all eggs develop throughout life—were nearly wiped out. This loss is permanent and cannot regenerate.
The number of atretic follicles (degenerating or non-developing) more than doubled, indicating not only depletion but active cell death.
The inactivated vaccine (Sinovac) also had measurable effects, but these were considerably milder than those seen with the mRNA vaccine.
This table is therefore not speculative—it is based on concrete numbers:
After administration of the mRNA vaccine, the key elements of fertility in the test animals were severely damaged.
Hormone Levels (AMH)
The level of AMH (Anti-Müllerian Hormone, a key marker of ovarian reserve) was:
– Significantly lower in the mRNA group (p < 0.001)
– Slightly reduced in the inactivated vaccine group, though not significantly
AMH levels in the granulosa cells of immature follicles were also decreased.
Signs of Inflammation and Apoptosis
TGF-β1, VEGF, and caspase-3 levels:
– Increased in both vaccine groups
– Far more pronounced in the mRNA group
The strong presence of caspase-3 indicated heightened apoptosis in ovarian cells.
Conclusions:
Both the mRNA and inactivated COVID-19 vaccines negatively affected ovarian reserve, but the mRNA vaccine had a much more severe impact.
The reduction in AMH levels and the destruction of primordial follicles suggest that fertility potential could be significantly diminished—especially if these effects apply to humans.
Primordial follicles do not regenerate, meaning the loss may be permanent.
Comparison with Previous Human Findings:
The study notes that COVID-19 vaccination has already been associated with menstrual irregularities in women. Some clinical studies have reported reduced AMH levels post-vaccination.
Meta-analyses found no significant impact of mRNA vaccines on IVF (in vitro fertilization) outcomes. However, these results came from hormonally stimulated environments (FSH treatment), which can mask underlying ovarian damage under natural conditions.
Authors’ Recommendation:
Further long-term human studies are needed, especially those examining natural menstrual cycles and fertility parameters (such as AMH levels and antral follicle counts) in vaccinated vs. unvaccinated women.
Finally – What Can You Do Now If You Don’t Want to Stay in Uncertainty?
We cannot know for certain to what extent the results of this rat study apply to humans. Hopefully not at all—or only minimally.
But we already see too many unanswered questions and far too little open conversation around this topic. Many young women, understandably, may now want clarity—especially in light of the Czech findings and this new animal study.
If you’ve received the COVID vaccine—especially multiple doses of an mRNA vaccine—and you don’t want to live in uncertainty, you have the option to take a closer look at your current reproductive health.
This is not about fear or anxiety—it’s about care and foresight.
Sometimes, the greatest relief comes from finally knowing the truth.
What Can You Do Now to Gain Clarity?
There are two simple, accessible tests you can request:
AMH Test (Anti-Müllerian Hormone): A blood test that indicates your ovarian reserve
Antral Follicle Count via Ultrasound: A transvaginal ultrasound, done early in the cycle, showing how many follicles are currently maturing
Based on these, a gynecologist or fertility specialist can give you a clearer picture of your reproductive state.
What Symptoms Might Suggest That Testing Is Especially Warranted?
– Irregular, prolonged, or missed periods
– Unusual PMS symptoms, hot flashes, or sleep disturbances
– Low libido, irritability, or early signs of menopause
– Difficulty conceiving within one year despite trying
These symptoms are not necessarily vaccine-related—but if they emerged after vaccination, you have every right to investigate.
And Finally:
This isn’t about blame. It’s not about what was taken, but about what might still be saved.
Your body is not replaceable. Your future is not a test zone. And your voice may matter now more than ever.
Dare to ask. Stand up for yourself. And, if needed, stand up for others too.
Because what you choose to do now may not only rewrite your own future—but that of your generation and those yet to come.